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Related Experiment Video

Updated: Jun 11, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Published on: January 24, 2025

[Otosyphilis].

Jens Højberg Wanscher¹, Christian E Faber

¹Odense Universitetshospital, Øre-, Naese- og Halskirurgisk Afdeling F, 5000 Odense C. wanscher@gmail.com

Ugeskrift for Laeger

|July 10, 2010

Summary

This summary is machine-generated.

Human immunodeficiency virus (HIV) patients can develop hearing loss and tinnitus from syphilis affecting the inner ear. Early treatment with antibiotics and prednisone significantly improved symptoms.

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Published on: November 3, 2009

Area of Science:

Neuroscience
Infectious Diseases
Otolaryngology

Background:

Inner ear syphilis is a rare but serious complication of syphilis infection.
Human immunodeficiency virus (HIV) infection can alter the presentation and progression of various opportunistic infections, including syphilis.

Observation:

A case study of an HIV-positive patient presenting with sensorineural hearing loss and tinnitus.
Standard audiological and neurological examinations, including otomicroscopy, tympanometry, ENT examination, caloric testing, and intracranial MRI, were normal.
Serological tests and cerebrospinal fluid analysis confirmed secondary or early latent syphilis.

Findings:

Audiometry revealed significant sensorineural hearing loss.
The patient experienced considerable improvement in hearing and a decrease in tinnitus after a ten-day course of antibiotics and prednisone.

Implications:

This case highlights the importance of considering syphilis in the differential diagnosis of hearing loss and tinnitus in HIV-positive individuals.
Prompt diagnosis and treatment of neurosyphilis are crucial for preventing irreversible neurological and audiological damage.
Combination therapy with antibiotics and corticosteroids may be effective in managing syphilitic inner ear disease.