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Published on: December 9, 2025
Craniofacial changes after 2 years of nasal continuous positive airway pressure use in patients with obstructive
Hiroko Tsuda1, Fernanda R Almeida, Toru Tsuda
1Department of Oral Health Sciences, The University of British Columbia, Vancouver, BC, Canada. htsuda@dent.kyushu-u.ac.jp
Insights
Long-term nasal continuous positive airway pressure (nCPAP) use in adults with obstructive sleep apnea (OSA) may alter craniofacial structures. These changes include reduced maxillary and mandibular prominence and altered dental arch relationships.
Area of Science:
- Orthodontics
- Sleep Medicine
- Craniofacial Biology
Background:
- Obstructive sleep apnea (OSA) is commonly treated with nasal continuous positive airway pressure (nCPAP).
- Previous research indicated midfacial hypoplasia in children using nCPAP.
Purpose of the Study:
- To evaluate craniofacial changes in adult OSA patients after prolonged nCPAP therapy.
Main Methods:
- Cephalometric radiographs of 46 Japanese adults using nCPAP for over 2 years were analyzed.
- Changes in facial height, interarch relationships, and tooth positions were assessed.
Main Results:
- Significant changes observed included maxillary retrusion, reduced maxillary-mandibular discrepancy, and retroclination of incisors.
- No significant correlation was found between craniofacial changes and demographic factors or nCPAP duration.
- Patients did not report permanent changes in occlusion or facial profile.
Conclusions:
- Prolonged nCPAP use (>2 years) may modify craniofacial form in OSA patients.
- Observed changes involve reduced prominence of maxilla and mandible and altered dental arch relationships.
Background:
Many patients with obstructive sleep apnea (OSA) use nasal continuous positive airway pressure (nCPAP) as a first-line therapy. Previous studies have reported midfacial hypoplasia in children using nCPAP. The aim of this study is to assess the craniofacial changes in adult subjects with OSA after nCPAP use.
Methods:
Forty-six Japanese subjects who used nCPAP for a minimum of 2 years had both a baseline and a follow-up cephalometric radiograph taken. These two radiographs were analyzed, and changes in craniofacial structures were assessed. The cephalometric measurements evaluated were related to face height, interarch relationship, and tooth position.
Results:
Most of the patients with OSA were men (89.1%), and the mean baseline values for age, BMI, and apnea-hypopnea index (AHI) were 56.3 ± 13.4 years, 26.8 ± 5.6 kg/m(2), and 42.0 ± 18.6/h. The average duration of nCPAP use was 35.0 ± 6.7 months. After nCPAP use, cephalometric variables demonstrated a significant retrusion of the anterior maxilla, a decrease in maxillary-mandibular discrepancy, a setback of the supramentale and chin positions, a retroclination of maxillary incisors, and a decrease of convexity. However, significant correlations between the craniofacial changes, demographic variables, or the duration of nCPAP use could not be identified. None of the patients self-reported any permanent change of occlusion or facial profile.
Conclusion:
The use of an nCPAP machine for > 2 years may change craniofacial form by reducing maxillary and mandibular prominence and/or by altering the relationship between the dental arches.
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