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Related Experiment Video

Updated: Jun 11, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Optimizing acromegaly treatment.

Marcello D Bronstein¹

¹Neuroendocrine Unit, Division of Endocrinology and Metabolism, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, S P, Brazil.

Frontiers of Hormone Research

|July 10, 2010

Summary

This summary is machine-generated.

Effective acromegaly treatment normalizes mortality by normalizing growth hormone (GH) and IGF-1 levels. Combining therapies like somatostatin analogs (SA) with pegvisomant (PEG-V) or cabergoline may improve outcomes.

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Last Updated: Jun 11, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Area of Science:

Endocrinology
Oncology

Background:

Acromegaly is a rare, disabling disease with high cardiovascular mortality.
Mortality risk is reduced to normal levels when GH and IGF-1 levels are normalized through treatment.

Purpose of the Study:

To review current therapeutic strategies for acromegaly control.
To explore combination therapies and surgical debulking for optimizing treatment outcomes.

Main Methods:

Review of epidemiological evidence and current therapeutic approaches for acromegaly.
Analysis of the efficacy of somatostatin analogs (SA), dopamine agonists (DA), and pegvisomant (PEG-V).

Main Results:

Somatostatin analogs (SA) control acromegaly in about two-thirds of patients.
Combination therapy (SA with PEG-V or DA) and surgical debulking show potential for enhanced control and overcoming resistance.

Conclusions:

Optimizing acromegaly control can be achieved through combination therapies and adjunct surgical debulking.
These strategies may improve patient outcomes and potentially reduce healthcare costs.