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Cystic Fibrosis: Pathogenesis

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Related Experiment Video

Updated: Jun 11, 2026

Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
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Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

Published on: August 15, 2025

Kawasaki disease: update on pathogenesis.

Rae S M Yeung1

  • 1Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada. rae.yeung@sickkids.ca

Current Opinion in Rheumatology
|July 10, 2010
PubMed
Summary

Recent studies reveal that T-cell activation regulation is key to Kawasaki disease susceptibility and severity. Identifying molecular players like ITPKC offers new diagnostic and therapeutic avenues for this childhood vasculitis.

Area of Science:

  • Immunology
  • Pediatric Vasculitis
  • Molecular Pathogenesis

Background:

  • Kawasaki disease is the leading cause of acquired heart disease in children, characterized by multisystem vasculitis.
  • Coronary artery damage is a primary concern, impacting cardiovascular health in affected children.
  • Genetic predisposition is recognized, but the precise mechanisms of susceptibility and disease outcome remain unclear.

Purpose of the Study:

  • To review recent advancements in understanding Kawasaki disease pathogenesis.
  • To identify molecular regulators of T-cell activation involved in disease.
  • To explore the impact of these molecular players on disease incidence and outcomes in humans and mouse models.

Main Methods:

  • Genetic analysis of Japanese children with Kawasaki disease.

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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

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Last Updated: Jun 11, 2026

Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
07:10

Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus

Published on: August 15, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

  • Utilizing a mouse model to study Kawasaki disease pathogenesis.
  • Investigating the role of T-cell activation and costimulation in disease susceptibility and severity.

    • Main Results:

    • Genetic analysis identified ITPKC (1,4,5-triphosphate 3-kinase C) as significantly associated with Kawasaki disease susceptibility and severity.
    • Regulation of T-cell activation, particularly costimulation, emerged as a critical factor in both human genetic studies and animal models.
    • These findings highlight T-cell activation pathways as central to Kawasaki disease development.

    Conclusions:

    • Understanding the molecular mechanisms of immune dysregulation in Kawasaki disease is crucial.
    • Advances in identifying molecular players will aid in developing better diagnostic and predictive tools.
    • This knowledge will facilitate more targeted and effective therapeutic strategies for improved patient outcomes.