Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RETRACTED: Sudha et al. Triazole Modified Tetraiodothyroacetic Acid Conjugated to Polyethylene Glycol, a Thyrointegrin α<sub>v</sub>β<sub>3</sub> Antagonist as a Radio- and Chemo-Sensitizer in Pancreatic Cancer. <i>Biomedicines</i> 2022, <i>10</i>, 795.

Biomedicines·2025
Same author

RETRACTED: Godugu et al. Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin Without Compromising Its Anticancer Efficacy in Breast Cancer. <i>Molecules</i> 2020, <i>25</i>, 2597.

Molecules (Basel, Switzerland)·2025
Same author

RETRACTED: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (<i>Allium sativum</i>): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. <i>Molecules</i> 2017, <i>22</i>, 2081.

Molecules (Basel, Switzerland)·2025
Same author

Editorial Expression of Concern: Nano-Targeted Delivery of Toremifene, an Estrogen Receptor-α Blocker in Prostate Cancer.

Pharmaceutical research·2025
Same author

Correction: Abou-ElNaga et al. Novel Nano-Therapeutic Approach Actively Targets Human Ovarian Cancer Stem Cells after Xenograft into Nude Mice. <i>Int. J. Mol. Sci</i>. 2017, <i>18</i>, 813.

International journal of molecular sciences·2025
Same author

RETRACTED: El-Far et al. Thymoquinone and Curcumin Defeat Aging-Associated Oxidative Alterations Induced by D-Galactose in Rats' Brain and Heart. <i>Int. J. Mol. Sci.</i> 2021, <i>22</i>, 6839.

International journal of molecular sciences·2024

Related Experiment Video

Updated: Jun 11, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Adhesion molecules: potential therapeutic and diagnostic implications.

Shaker A Mousa1

  • 1Pharmaceutical Research Institute at Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|July 10, 2010
PubMed
Summary

Cell adhesion molecules (CAMs) and extracellular matrix (ECM) proteins are crucial in diseases. Their roles in cell processes and therapeutic potential are highlighted, focusing on integrins and GP IIb/IIIa.

More Related Videos

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Related Experiment Videos

Last Updated: Jun 11, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Pathology

Background:

  • Cell adhesion molecules (CAMs) and extracellular matrix (ECM) proteins are integral to numerous physiological and pathological processes.
  • Dysregulation of CAMs and ECM is implicated in diverse diseases, including cancer metastasis, cardiovascular disorders, inflammation, and neurodegeneration.
  • Key molecules like platelet glycoprotein (GP)IIb/IIIa have shown significant roles in thromboembolic disorders.

Purpose of the Study:

  • To review the documented roles of CAMs and ECM proteins in pathological processes.
  • To highlight the diagnostic and therapeutic potential of soluble adhesion molecules and integrins.
  • To emphasize the structure-function relationships of CAMs and ECM in cell adhesion and signaling.

Main Methods:

  • Literature review and synthesis of existing research on CAMs and ECM.
  • Analysis of the involvement of specific adhesion molecules, such as GP IIb/IIIa and integrins, in disease pathogenesis.
  • Examination of structure-function relationships and signaling pathways.

Main Results:

  • CAMs and ECM proteins are critical mediators of angiogenesis, thrombosis, inflammation, apoptosis, cell migration, and proliferation.
  • These molecules contribute to a wide spectrum of diseases, from ocular conditions and metastasis to cardiovascular and neurodegenerative disorders.
  • Soluble adhesion molecules are increasingly utilized as diagnostic markers for cellular insult.

Conclusions:

  • CAMs and ECM proteins represent significant targets for therapeutic and diagnostic strategies.
  • Integrins, a major class of CAMs, are particularly emphasized for their roles in various diseases.
  • Understanding the structure-function and signaling of CAMs and ECM is key to developing novel treatments.