Related Experiment Video
Updated: Jun 11, 2026
The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
Published on: April 19, 2024
[Efffect of baicalin on antipyresis and influence on cytokine]
1Department of Pharmacology, Medical School of Yangzhou University, Yangzhou 225001, China. lqngg@126.com
Objective:
To study the antipyretic effect of baicalin in inhibiting yeast-induced fever in rats and the influence on inflammatory cytokine, then explore the possible mechanism of baicalin in inhibiting yeast-induced fever in rats.
Methods:
Rat modles of pyrexia were established by subcutaneous injection of yeast (2 g x kg(-1)); the rats of were divided into the normal control, model, baicalin high, medium and low-dose group and the effect of baicalin on the changes of the rats' temperature were observed. Dual antibody ELISA method was used to test the changes of IL-6, IL-1beta and TNF-alpha contents in in serum , hypothalamus and cerebral spinal fluid (CSF). Then analyze the correlation between the inhibition ratio of temperature heighten on three different dose of baicalin and the inhibition ratio of the contents heighten on IL-6, IL-1beta and TNF-alpha.
Result:
The high dose of baicalin significantly inhibited the yeast-induced fever of rats, and decresesed IL-6, IL-1beta and TNF-alpha contents in serum, hypothalamus and CSF. The inhibition ratio of temperature heighten of baicalin had direct correlation with the inhibition ratio of the heighten on IL-1beta content in serum, hypothalamus and CSF (r = 0.873, P < 0.05), also dose TNF-alpha (r = 0.862, P < 0.01).
Conclusion:
Baicalin may have obvious antipyretic effect by decreasing the increasing contents of IL-1beta and TNF-alpha in rats.
Insights
Baicalin demonstrates significant antipyretic effects in rats by reducing fever and lowering inflammatory cytokines, specifically Interleukin-1 beta (IL-1beta) and Tumor Necrosis Factor-alpha (TNF-alpha). This suggests a potential therapeutic role for baicalin in managing fever.
Area of Science:
- Pharmacology
- Immunology
- Neuroscience
Context:
- Fever is a common symptom of inflammation.
- Yeast-induced fever in rats is a standard model for studying antipyretic agents.
- Inflammatory cytokines play a crucial role in the fever response.
Purpose:
- To investigate the antipyretic efficacy of baicalin.
- To assess baicalin's impact on key inflammatory cytokines (IL-6, IL-1beta, TNF-alpha).
- To elucidate the mechanism underlying baicalin's fever-reducing action.
Summary:
- Baicalin administration significantly reduced yeast-induced fever in rats.
- Baicalin decreased levels of IL-6, IL-1beta, and TNF-alpha in serum, hypothalamus, and cerebrospinal fluid (CSF).
- A direct correlation was observed between baicalin's fever-reducing effect and its ability to lower IL-1beta and TNF-alpha levels.
Impact:
- Baicalin exhibits notable antipyretic properties.
- The findings suggest baicalin's therapeutic potential in fever management.
- Baicalin's mechanism involves the modulation of inflammatory cytokine production.
Related Concept Videos
01:30Inhibitors of Viral Protein Synthesis
01:22Methods of reducing fever
Pharmacological Methods of Reducing Fever: