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Updated: Jun 11, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
08:43

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

Published on: January 19, 2016

Improved arene fluorination methodology for I(III) salts.

Bijia Wang1, Linlin Qin, Kiel D Neumann

  • 1Department of Chemistry and Nebraska Center for Materials and Nanoscience, University of Nebraska, Lincoln, Nebraska 68588-0304, USA.

Organic Letters
|July 13, 2010
PubMed
Summary

Improved yields of fluorinated arenes are achieved using diaryliodonium salts with low polarity aromatic solvents or by removing inorganic salts. This method is suitable for radiotracer synthesis conditions.

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