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Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
Benign nodular goiter with spindle cell component
Mitsuyoshi Hirokawa1, Reiji Haba, Yoshio Kushida
1Department of Diagnostic Pathology, Kuma Hospital, Kobe, Japan. mhirokawa@kuma-h.or.jp
Abstract:
We report three benign nodular goiters associated with spindle cell component. The spindle cells were bland, and showed short fascicular pattern or formed small nests. The cytoplasm was pale or clear. A transition between follicular cells and the spindle cells was observed. Immunohistochemically, they were positive for thyroglobulin and thyroid transcription factor-1. They did not react against CD34. Ki-67 (MIB-1) labeling indexes were less than 1%. We thought that the spindle cells are derived from follicular cell and non-neoplastic, and it is important to recognize this lesion to distinguish from aggressive and lethal components seen in papillary carcinoma or anaplastic carcinoma.
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