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Updated: Jun 11, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Corneal squamous cell carcinoma in two dogs
Naoaki Takiyama1, Eri Terasaki, Masami Uechi
1Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, 252-8510, Japan. takiyama.naoaki@nihon-u.ac.jp
Purpose:
To report two cases of corneal squamous cell carcinoma (SCC) in dogs.
Methods:
Corneal tumors were resected by superficial keratectomy in two cases. Immunohistochemistry of the corneal tissues was performed using anti-p53 antibody.
Results:
The prominent features of the cases were a clinical history of pigmentary keratitis and chronic keratitis. In each case, a corneal mass was surgically removed with a superficial keratectomy and histologically diagnosed as corneal SCC. Both masses were negative for p53. To reduce chronic corneal irritation, 0.1% hyaluronate sodium ophthalmic solution was applied. After more than 15 months of postsurgical follow-up there has been no recurrence of either neoplasm.
Conclusion And Discussion:
Chronic corneal irritation was suspected as the primary etiology for the corneal SCC. Appropriate surgical removal of the mass and subsequent conservative treatment for keratitis provided effective therapy in these two cases.
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