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Human Virome

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...

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Updated: Jun 11, 2026

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

Assessing the human immune system through blood transcriptomics.

Damien Chaussabel¹, Virginia Pascual, Jacques Banchereau

¹Baylor Institute for Immunology Research and Baylor Research Institute, 3434 Live Oak, Dallas, TX 75204, USA. damienc@baylorhealth.edu

|July 13, 2010

Summary

This summary is machine-generated.

Analyzing blood gene expression provides a full picture of immune system health and disease. This review covers how blood transcriptome research identifies new treatments and biomarkers for autoimmune and infectious diseases.

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Area of Science:

Immunology
Genomics
Transcriptomics

Background:

The immune system's status is critical in health and disease.
Blood serves as a key indicator of immune system activity.
Genome-wide transcript abundance analysis in blood offers a comprehensive view.

Purpose of the Study:

To review the application of blood transcriptome analysis in autoimmunity and infectious diseases.
To highlight the identification of therapeutic targets and biomarker signatures.
To discuss advancements in blood transcriptome research.

Main Methods:

Genome-wide assessment of transcript abundance in blood.
Review of existing studies utilizing blood transcriptome data.
Analysis of technological and methodological progress.

Main Results:

Blood transcriptome analysis is effective for understanding immune status.
This approach has successfully identified potential therapeutic targets.
Biomarker signatures for disease have been discovered using this method.

Conclusions:

Blood transcriptome profiling is a powerful tool in immunology.
It aids in the discovery of novel treatments and diagnostic markers.
Future technological advances will further enhance this research field.