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Updated: Jun 11, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

[Urticaria: not usually an allergic reaction].

Géanne Krabben¹, Paul L P Brand

¹Isala Klinieken, Amalia kinderafdeling, Zwolle, the Netherlands.

Nederlands Tijdschrift Voor Geneeskunde

|July 13, 2010

Summary

Urticaria in children is often triggered by viral infections, not allergies. Antihistamines effectively treat both acute and chronic urticaria, with most chronic cases being idiopathic.

Area of Science:

Pediatrics
Dermatology
Allergy and Immunology

Background:

Urticaria is a common skin condition in children.
Distinguishing between acute and chronic urticaria is crucial for management.
Understanding the underlying causes, such as viral infections versus idiopathic factors, guides treatment strategies.

Observation:

Three pediatric patients (ages 4, 7, 8) presented with urticarial symptoms.
The oldest boy had chronic urticaria with angio-oedema; the younger boy had chronic urticaria.
The girl presented with acute urticaria secondary to a common cold, with a history of eczema.

Findings:

All three children responded positively to antihistamine treatment.
Acute urticaria in children is frequently associated with viral infections.

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The majority of chronic urticaria cases in children are idiopathic, meaning the cause is unknown.

Implications:

Antihistamines are a primary treatment modality for pediatric urticaria.
Extensive investigations are typically unnecessary for acute urticarial episodes in children.
Long-term antihistamine therapy is indicated for managing idiopathic chronic urticaria in pediatric patients.