Related Experiment Video
Updated: Jun 11, 2026
18:40
Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
[Diagnostic options in chronic recurrent multifocal osteomyelitis: case reports]
M Kokavec1, H Sameková, E Kosková
1Ortopedická klinika LFUK a DFNsP, Bratislava. kokavec@dfnsp.sk
Summary
Chronic recurrent multifocal osteomyelitis (CRMO) is a severe bone condition. Early diagnosis and interdisciplinary collaboration are key to successfully managing CRMO in pediatric patients.
Area of Science:
- Pediatric rheumatology
- Orthopedic surgery
- Medical imaging
Background:
- Chronic recurrent multifocal osteomyelitis (CRMO) is the most severe form of chronic non-bacterial osteomyelitis.
- CRMO commonly affects long bone metaphyses in children and adolescents but can manifest skeleton-wide and in other organs.
- Clinical diagnosis of CRMO is challenging due to variable signs and disease course.
Observation:
- The study details three pediatric cases of CRMO with diverse skeletal localizations.
- Case 1: CRMO in the tibia, femur, sacrum, and clavicle.
- Case 2: CRMO in the tibia, foot joints, and femur.
- Case 3: CRMO in the pubic ramus and ischium.
Findings:
- Interdisciplinary collaboration enabled accurate CRMO diagnosis in all three cases.
- Successful management was achieved for all patients.
- The rarity of CRMO hinders randomized controlled trials for precise therapeutic guidelines.
Implications:
- Highlights the importance of a multidisciplinary approach for diagnosing and managing CRMO.
- Suggests meta-analysis of published cases as a viable alternative for developing treatment strategies.
- Emphasizes the need for increased awareness and research into this rare pediatric condition.
Related Concept Videos
01:28Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...