Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility and Acceptability of mPallCare<i>,</i> a Digital Health Intervention for People Living With Advanced Cancer in a Refugee Settlement in Uganda: Mixed Methods Study.

JMIR mHealth and uHealth·2026
Same author

Travel health needs and experiences of people living with Parkinson's disease and their carers: an exploratory qualitative study.

Journal of travel medicine·2026
Same author

"…I feel like I am just staying here waiting for death": A qualitative study of the lived experiences of people with advanced illness in refugee settlements in Uganda.

PLOS global public health·2025
Same author

Community-based palliative care in Kenya: its history, current status, challenges and future.

Annals of palliative medicine·2025
Same author

The SUGAR handshake intervention to prevent hypoglycaemia in elderly people with type 2 diabetes: process evaluation within a pragmatic randomised controlled trial.

BMC geriatrics·2025
Same author

The Onerous task of managing paroxysmal nocturnal hemoglobinuria in a Low resource setting: a case report. A hematologist's experience.

African health sciences·2025

Related Experiment Video

Updated: Jun 11, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Advancing drug availability-experiences from Africa.

Richard A Powell1, Richard Mugula Kaye, Henry Ddungu

  • 1African Palliative Care Association, Kampala, Uganda. tony.powell@apca.org.ug

Journal of Pain and Symptom Management
|July 13, 2010
PubMed
Summary
This summary is machine-generated.

Opioid analgesics are scarce in many African nations, hindering pain management. Workshops by the African Palliative Care Association identified barriers and fostered action plans to improve essential medication availability.

More Related Videos

Comprehensive &amp; Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Related Experiment Videos

Last Updated: Jun 11, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Comprehensive &amp; Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
05:46

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Area of Science:

  • Global Health
  • Pharmacology
  • Public Health Policy

Background:

  • International health authorities recognize insufficient analgesic availability, particularly opioids, for pain management globally.
  • Morphine consumption in Africa is significantly lower than the global average, indicating substantial barriers to opioid availability.
  • The African Palliative Care Association has actively worked since 2006 to address these challenges through regional workshops.

Purpose of the Study:

  • To identify country-specific barriers to the accessibility of opioids and other essential medications in Africa.
  • To support workshop participants in developing actionable plans to overcome identified impediments to drug availability.
  • To assess progress and persistent challenges in improving essential medication access across the continent.

Main Methods:

  • Conducting three regional drug availability workshops hosted by the African Palliative Care Association since 2006.
  • Utilizing an interactive format to facilitate the identification of country-specific barriers.
  • Guiding participants in the development of action plans to address identified obstacles to medication accessibility.

Main Results:

  • Successful identification of numerous country-specific barriers hindering opioid and essential medication availability.
  • Development and initial implementation of action plans by workshop participants.
  • Emergence of several successes resulting from the implementation of these action plans, despite ongoing challenges.

Conclusions:

  • While progress has been made, significant challenges persist in ensuring adequate analgesic availability in Africa.
  • The establishment of supportive policy environments is crucial for improving drug access.
  • Effective educational initiatives and robust supply-chain solutions are necessary to overcome persistent obstacles to essential medication availability.