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Related Concept Videos

Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...

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Nephrogenic adenoma.

Waqas Amin1, Anil V Parwani

  • 1Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. aminw@upmc.edu

Pathology, Research and Practice
|July 13, 2010
PubMed
Summary
This summary is machine-generated.

Nephrogenic adenoma, a rare benign urinary tract lesion, is increasingly thought to arise from implanted renal tubular cells. Accurate diagnosis through histology and immunohistochemistry is crucial for differentiating it from malignant tumors.

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Area of Science:

  • Uropathology
  • Surgical Pathology
  • Oncology

Background:

  • Nephrogenic adenoma is an uncommon benign bladder lesion.
  • Its exact pathogenesis remains unclear, with embryological and inflammatory theories proposed.
  • The theory of origin from implanted exfoliated renal tubular cells is gaining acceptance.

Purpose of the Study:

  • To review the pathogenesis of nephrogenic adenoma.
  • To emphasize the diagnostic criteria for nephrogenic adenoma.
  • To highlight the importance of differentiating nephrogenic adenoma from malignant lesions.

Main Methods:

  • Histological examination is the primary diagnostic method.
  • Immunohistochemistry plays a supportive role in diagnosis.
  • Differential diagnosis is considered in patients with urinary tract symptoms.

Main Results:

  • Histological assessment is crucial for accurate identification.
  • Immunohistochemistry aids in confirming the diagnosis when needed.
  • Nephrogenic adenoma must be considered in the differential diagnosis of urinary tract lesions.

Conclusions:

  • The implantation of renal tubular cells is a leading theory for nephrogenic adenoma development.
  • Histological evaluation is essential for distinguishing nephrogenic adenoma from malignancies.
  • Consideration of nephrogenic adenoma in the differential diagnosis is vital for appropriate patient management.