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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
Published on: October 17, 2025
5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder
Taro Endo1, Hideaki Kitamura, Ryu Tamura
1Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. tarou@med.niigata-u.ac.jp
Abstract:
We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype.
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