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Updated: Jun 11, 2026

Production of Modified Autologous Conditioned Serum and Ex Vivo Assessment of Its Healing Potential in Murine Corneal Epithelium
Published on: March 24, 2023
Effectiveness of 100% autologous serum drops in ocular surface disorders
A Jover Botella1, J F Márquez Peiró, K Márques
1Servicio de Farmacia, Hospital General Universitario de Alicante, Alicante, España.
Objective:
To evaluate the effectiveness of 100% autologous serum eye drops for the treatment of various ocular surface disorders.
Methods:
A descriptive prospective observational study carried out from May 2005 to February 2009 which included patients with ocular surface disorders treated with single-dose autologous serum eye drops. Treatment effectiveness was evaluated by using a clinical questionnaire in order to assess symptoms experienced by patients at the beginning and end of treatment.
Results:
A total of 15 patients (24 eyes) were evaluated. Clinical symptoms such as redness, burning, sharp pain and tired eyes improved in 100% of the patients, whereas dryness and sandy/gritty sensation improved in 92% of the patients. The overall improvement of clinical symptoms was worth the inconvenience of venipuncture according to 66.7% of the patients. Regarding tolerance for autologous serum eye drops, only one patient experienced some discomfort when using the single-dose eye drops.
Conclusion:
The treatment with 100% autologous serum eye drops improved ocular symptoms for most patients.
