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Related Experiment Video

Updated: Jun 11, 2026

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Published on: June 16, 2022

[Hydroxyethyl starch].

F Wierre¹, E Robin, O Barreau

¹Pôle d'anesthésie-réanimation, hôpital Huriez, CHRU de Lille, rue Polonovski, 59037 Lille cedex, France.

Annales Francaises D'Anesthesie Et De Reanimation

|July 13, 2010

Summary

This summary is machine-generated.

Recent hydroxyethyl starch (HES) formulations aim to minimize side effects like renal dysfunction and hemostasis issues. Newer HES solutions focus on reduced molecular weight and modified substitution rates for safer plasma volume expansion.

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Area of Science:

Pharmacology and Biophysics
Clinical Medicine

Context:

Hydroxyethyl starch (HES) has been used for plasma substitution since 1970.
Recent advancements in HES aim to improve safety and efficacy.
The debate between crystalloids and colloids, including HES, continues in clinical practice.

Purpose:

To review current knowledge on recent hydroxyethyl starch (HES) formulations.
To analyze the biophysics, pharmacology, toxicity, and clinical effects of HES.
To discuss the evolving role and limitations of HES in medical applications.

Summary:

Newer HES generations feature decreased molecular weight and altered molar substitution rates.
The primary goal of recent HES development is to reduce side effects, notably hemostasis and renal dysfunction.
The latest innovations include "balanced" HES solutions.

Impact:

Improved understanding of HES safety and efficacy in intensive care and perioperative settings.
Guidance on the appropriate use of modern HES products.
Informing future research and development of plasma volume expanders.