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Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Related Experiment Video

Updated: Jun 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Overview of platelet transfusion.

Jeffrey McCullough¹

¹Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. mccul001@umn.edu

Seminars in Hematology

|July 13, 2010

Summary

Platelet transfusions prevent bleeding in patients with low platelet counts, typically recommended at 10,000/microL. Dosing strategies impact transfusion frequency but not bleeding risk.

Area of Science:

Hematology
Transfusion Medicine
Oncology

Background:

Platelet transfusions are crucial for preventing bleeding in patients with thrombocytopenia, particularly those undergoing chemotherapy or hematopoietic stem cell transplant.
Bleeding risk is minimal until platelet counts drop below 5,000/microL in stable patients, but clinical complications often necessitate transfusions at higher levels.

Purpose of the Study:

To outline the indications and dosing strategies for prophylactic platelet transfusions.
To discuss the utility of platelet transfusions in specific patient populations with bleeding disorders.

Main Methods:

Review of current clinical practices and guidelines for platelet transfusion.
Analysis of bleeding risk associated with varying platelet counts and transfusion doses.

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Last Updated: Jun 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Main Results:

Prophylactic platelet transfusion is generally recommended when platelet counts reach 10,000/microL.
Standard, half, or double doses of platelets result in similar bleeding likelihood, but affect transfusion frequency.
Prophylactic transfusion is not recommended for most platelet function defects; it is primarily indicated for severe bleeding treatment.

Conclusions:

Platelet transfusion guidelines are based on balancing bleeding risk and clinical complications.
Dosing adjustments can optimize transfusion schedules without altering efficacy.
Transfusion is a critical intervention for managing severe bleeding in specific hematologic conditions.