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Updated: Jun 11, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Is there any role for antithymocyte induction in renal transplantation?
N A Neidlinger1, H W Sollinger
1University of Wisconsin Department of Surgery, Division of Organ Transplantation, Madison, Wisconsin 53792-7375, USA. Nikole@surgery.wisc.edu
Abstract:
The use of an antibody induction agent in kidney transplantation lowers the risk of an acute rejection episode and may improve graft outcomes. Antithymocyte globulin (ATG) is the most commonly used antibody induction agent for kidney transplantation in the United States, despite its significant side effect profile and cost compared to the interleukin-2 receptor antagonists (IL2-RA). Our review suggests the IL2-RA are safe and well tolerated, and provide equal clinical benefit to ATG at a lower cost. We propose that there is insufficient evidence to justify the use of ATG induction in kidney transplantation.
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