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Related Experiment Video

Updated: Jun 11, 2026

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

Published on: January 27, 2026

Modified perfusion fluid for renal transplantation in developing countries: our initial experience.

M K Islam¹, A T M N Rahman, N U M Arif

¹Transplant Division, Department of Urology, National Institute of Kidney Diseases and Urology, Sher-E-Banglanagar, Bangladesh. kamruluro@gmail.com

Transplantation Proceedings

|July 13, 2010

Summary

A new, cost-effective perfusion fluid effectively preserves kidneys for transplantation, showing comparable results to standard solutions. This innovation is crucial for developing countries lacking access to commercial organ preservation fluids.

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Last Updated: Jun 11, 2026

Normothermic Machine Perfusion of Rat Kidneys for Transplantation

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Published on: January 27, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation

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Published on: July 15, 2015

An Open-Source Normothermic Perfusion System Designed for Research Scientists

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Published on: July 18, 2025

Area of Science:

Transplantation immunology
Organ preservation solutions
Biochemistry of preservation fluids

Background:

Organ preservation is critical for successful transplantation.
Commercial perfusion fluids are often unavailable or expensive in developing nations.
Standard solutions like Hartmann's lack adequate organ preservation qualities.

Purpose of the Study:

To develop a modified, cost-effective perfusion fluid for organ preservation.
To assess the efficacy of the modified fluid in renal transplantation.

Main Methods:

Hartmann's solution was modified aseptically by adding potassium chloride, magnesium sulfate, mannitol, dexamethasone, and insulin.
The resulting hypertonic solution's composition was similar to Marshall's solution.
The modified fluid was used in 14 renal transplantation operations.

Main Results:

The modified perfusion fluid protected kidneys for over 4 hours (mean cold ischemia time 187.50 ± 30.58 minutes).
No post-transplantation graft function deterioration was observed.
Graft function was comparable to those preserved with Collin's solution, with excellent early creatinine reduction and levels at 21 days.

Conclusions:

The modified perfusion fluid is effective and safe for kidney preservation.
Its low cost and ease of preparation make it suitable for transplantation in resource-limited settings.
This addresses the critical need for accessible organ preservation solutions in developing countries.