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Updated: Aug 16, 2026

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
Published on: December 20, 2021
Druckery slope controlled by mitotic rate of enzymatically-altered foci
1Health and Safety Research Division, Oak Ridge National Laboratory, TN 37831-6109.
Abstract:
Data on hepatocellular foci and tumors for four hepatocarcinogens are analyzed within the framework of a two-mutation model of oncogenesis to determine the biological factor(s) that control the values of N in Druckery's formula DTN = K, where T is the time to 50% tumor incidence at a daily dose D. The two-mutation oncogenic model was found to adequately reproduce the empirical data for all four hepatocarcinogens. The controlling factor of the Druckery slope N was found to be the mitotic rate (MRI) of hepatocellular foci, where MRI = CD1/N, C is a chemical-dependent constant, D is dose, and N is the Druckery slope.
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