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Updated: Jun 11, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
T helper cell differentiation: understanding the needs of hierarchy
Thomas Weichhart1, Marcus D Säemann
1Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. thomas.weichhart@meduniwien.ac.at
Abstract:
In this issue of Immunity, Lee et al. (2010) demonstrate that the mammalian Target of Rapamycin Complex 2 promotes the differentiation of T helper 1 (Th1) cells via the kinase Akt, whereas it independently fosters Th2 cell generation via another kinase, PKC-theta.
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