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Related Concept Videos

Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview

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Related Experiment Video

Updated: Jun 11, 2026

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
08:22

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

An IL-1beta-dependent switch in innate mucosal immunity?

James P Di Santo1

  • 1Innate Immunity Unit, Institut Pasteur, F-75724 Paris, France. james.di-santo@pasteur.fr

Immunity
|July 13, 2010
PubMed
Summary

Interleukin-1beta (IL-1beta) plays a key role in the development of innate lymphoid cells (ILCs). This study reveals IL-1beta

Area of Science:

  • Immunology
  • Cell Biology
  • Innate Immunity

Background:

  • Mucosal-associated innate lymphoid cells (ILCs) are crucial for immune responses.
  • ILCs producing IL-17, IL-22, and IFN-gamma are of significant research interest.
  • Understanding ILC development mechanisms is vital for mucosal immunity.

Discussion:

  • Hughes et al. (2010) investigated the regulatory mechanisms of ILC development.
  • The study focused on the role of cytokines in ILC differentiation.
  • IL-1beta's influence on ILC function was a central point of investigation.

Key Insights:

  • A novel role for IL-1beta in regulating IL-22-producing ILCs was identified.
  • IL-1beta acts as a critical signaling molecule in ILC development.

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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

  • This finding sheds light on the intricate pathways governing ILC populations.

    • Outlook:

    • Further research can explore therapeutic strategies targeting IL-1beta for immune modulation.
    • Understanding IL-1beta's role may lead to new treatments for inflammatory and autoimmune diseases.
    • Future studies could elucidate downstream signaling pathways of IL-1beta in ILCs.