Cardiovascular risk in women with diabetes

A A Rivellese1, G Riccardi, O Vaccaro

  • 1Department of Clinical and Experimental Medicine, Federico II University of Naples, Napoli, Italy. rivelles@unina.it

Insights

Diabetic women face higher cardiovascular disease risks than men, with factors like clustered risks and care disparities contributing. Early detection and gender-specific strategies are crucial for preventing cardiovascular deaths in this population.

Area of Science:

  • Endocrinology
  • Cardiology
  • Public Health

Background:

  • Diabetes mellitus significantly elevates cardiovascular disease (CVD) risk in women, nearly erasing gender-based differences seen in non-diabetic individuals.
  • Diabetic women exhibit a higher prevalence, clustering, and severity of cardiovascular risk factors compared to diabetic men, potentially due to biological and behavioral influences.

Purpose of the Study:

  • To review data on cardiovascular risk factors and outcomes in diabetic women compared to men.
  • To highlight disparities in healthcare access, quality, and effectiveness that disadvantage diabetic women.
  • To emphasize the preventability of a substantial number of CVD deaths in diabetic women.

Main Methods:

  • Review of existing data and literature on cardiovascular disease in diabetic populations.
  • Comparative analysis of risk factors, disease prevalence, and mortality between diabetic men and women.
  • Assessment of healthcare disparities impacting diabetic women's cardiovascular health.

Main Results:

  • Cardiovascular risk factors are more prevalent, cluster more frequently, and are more severe in diabetic women than in men.
  • Diabetic women face disadvantages due to disparities in healthcare accessibility, quality, and potentially effectiveness.
  • A significant proportion of cardiovascular disease deaths among diabetic women are preventable.

Conclusions:

  • Urgent attention is needed for risk factor detection and management in diabetic women.
  • Timely diagnosis and treatment of coronary heart disease (CHD) are critical for diabetic women.
  • Development and implementation of gender-specific guidelines and measures are recommended to improve cardiovascular outcomes for diabetic women.

Related Concept Videos

Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.