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Updated: Jun 11, 2026
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Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
Cerebral infarction in Duchenne muscular dystrophy
Nina Tsakadze1, Lara W Katzin, Sendhil Krishnan
1Department of Neurology, University of South Florida College of Medicine, 2 Tampa General Circle, Tampa, FL 33606, USA.
Summary
Duchenne muscular dystrophy (DMD) patients rarely experience cerebral infarction (CI). This case highlights a pontine infarct in a DMD patient with advanced cardiomyopathy (CMO), suggesting a potential link.
Area of Science:
- Neurology
- Cardiology
- Genetics
Background:
- Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder causing progressive muscle weakness.
- Cardiomyopathy (CMO) is a frequent complication in DMD patients.
- Cerebral infarction (CI) is an uncommon manifestation in DMD.
Observation:
- This report details a rare case of pontine infarct (cerebral infarction) in a patient with advanced DMD and CMO.
- The patient presented with neurological symptoms indicative of a stroke.
Findings:
- The pontine infarct occurred in the context of severe cardiac dysfunction.
- Review of existing literature suggests a potential association between advanced CMO and CI in DMD, though rare.
Implications:
- This case underscores the importance of considering cerebrovascular events in DMD patients, particularly those with significant cardiac involvement.
- Further research is warranted to elucidate the mechanisms linking DMD-associated CMO and CI.
- Enhanced vigilance for neurological complications may improve patient outcomes in DMD.
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