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Updated: Jun 11, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
New approaches to the diagnosis of sleep-disordered breathing in children
David Gozal1, Leila Kheirandish-Gozal
1Department of Pediatrics and Comer Children's Hospital, Pritzker School of Medicine, The University of Chicago, IL 60637, USA. dgozal@uchicago.edu
Insights
Pediatric obstructive sleep apnea syndrome (OSAS) is common, but diagnosing it with overnight polysomnography (NPSG) is challenging. New diagnostic methods are needed for better evaluation of sleep-disordered breathing in children.
Area of Science:
- Pediatric pulmonology
- Sleep medicine
- Diagnostic technology
Background:
- Sleep-disordered breathing (SDB) and obstructive sleep apnea syndrome (OSAS) are prevalent in children.
- Current diagnostic methods, including clinical assessment and overnight polysomnography (NPSG), have limitations.
Purpose of the Study:
- To discuss novel approaches for diagnosing pediatric SDB.
- To stimulate the development of improved diagnostic technologies.
- To define a more pragmatic and reliable diagnostic approach for pediatric SDB.
Main Methods:
- Discussion of novel approaches for evaluating pediatric SDB.
- Review of limitations of current diagnostic standards (clinical assessment, NPSG).
Main Results:
- Current diagnostic methods for pediatric SDB, particularly OSAS, face significant obstacles.
- NPSG, the gold standard, is limited by availability, cost, and inconvenience.
- Novel approaches are needed to overcome these diagnostic challenges.
Conclusions:
- There is a critical need for improved diagnostic technologies for pediatric SDB.
- Developing more pragmatic and reliable diagnostic approaches is essential for timely diagnosis and treatment.
- Further research should focus on innovative methods for evaluating SDB in children.
Abstract:
Sleep-disordered breathing in general and particularly, obstructive sleep apnea syndrome (OSAS) are highly prevalent conditions in children. Current diagnostic approaches range from exclusively using clinical presentation and physical examination to the current "Gold Standard" of overnight polysomnography (NPSG). But while it is clear that the former is fraught with major limitations, the latter is also associated with significant obstacles, such as relative unavailability of appropriately equipped sleep laboratories and trained personnel, the labor intensive nature of NPSG and its inconvenience, and, of course, the high cost of the procedure. These limitations are detrimental to timely diagnosis and treatment. Novel approaches to the evaluation of community-based and clinically referred pediatric populations are discussed and should stimulate the field in the search for improved diagnostic technologies and delineation of a more pragmatic and reliable diagnostic approach for pediatric SDB.
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