Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond amyloid and tau: synaptic and neurodegenerative biomarkers shape MCI progression.

Molecular psychiatry·2026
Same author

Language and communication disorders in dementia with Lewy bodies versus Alzheimer's disease: Objective screening and subjective perspectives of patients, their caregivers and clinicians.

Journal of Alzheimer's disease : JAD·2026
Same author

EU-wide external quality assessment study on the sensitivity and specificity of different DNA amplification protocols for the detection of Borrelia burgdorferi sensu lato.

Ticks and tick-borne diseases·2026
Same author

Probing biomass mimic guaiacol confinement and interactions in ZSM-5 zeolite.

Materials chemistry frontiers·2026
Same author

Exploration of geographical population structure of <i>Anaplasma phagocytophilum</i>: Insights from 12 newly sequenced European human and bovine genome assemblies.

Current research in parasitology & vector-borne diseases·2026
Same author

Performance of the French national hospital discharge database algorithm to identify hospitalised Lyme borreliosis cases, France, 2017-2018.

BMC infectious diseases·2026
Same journal

Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

Journal of the neurological sciences·2026
Same journal

Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

Journal of the neurological sciences·2026
Same journal

Comment on "Excellent agreement between automated deep learning-based and manual diffusion-weighted imaging infarct volume measurements in hyperacute stroke".

Journal of the neurological sciences·2026
Same journal

Shifting from alteplase to tenecteplase in acute ischemic stroke: Progress, promise, and perils.

Journal of the neurological sciences·2026
Same journal

Time-resolved GluCEST MRI of acute glutamate-related signal changes following kainic acid administration.

Journal of the neurological sciences·2026
Same journal

Comment on "Real-world timing of early anticoagulation therapy in intracerebral hemorrhage patients with atrial fibrillation".

Journal of the neurological sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

Lyme optic neuritis.

Frédéric Blanc1, Laurent Ballonzoli, Christophe Marcel

  • 1Department of Neurology, University Hospital of Strasbourg, Strasbourg, France. Frederic.Blanc@chru-strasbourg.fr

Journal of the Neurological Sciences
|July 13, 2010
PubMed
Summary
This summary is machine-generated.

Lyme optic neuritis (ON) is rare, but prompt diagnosis and treatment with ceftriaxone can restore vision. Early antibiotic therapy is crucial for a good visual outcome in neuroborreliosis affecting the optic nerve.

More Related Videos

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)

Published on: November 20, 2016

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Related Experiment Videos

Last Updated: Jun 11, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
12:23

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

Published on: April 14, 2014

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
06:49

The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)

Published on: November 20, 2016

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Neurology

Background:

  • Lyme optic neuritis (ON) is an uncommon manifestation of Lyme disease.
  • Isolated cases are infrequently reported, presenting diagnostic challenges.
  • Distinguishing ON from other demyelinating conditions is critical.

Purpose of the Study:

  • To report two cases of isolated Lyme optic neuritis.
  • To highlight the diagnostic criteria and treatment outcomes.
  • To emphasize the importance of early diagnosis and specific treatment for visual recovery.

Main Methods:

  • Case series describing two patients with isolated Lyme ON.
  • Diagnostic evaluation included exclusion of multiple sclerosis and neuromyelitis optica.
  • Etiological diagnosis based on European case definition criteria for neuroborreliosis.
  • Serological testing of serum and cerebrospinal fluid, and assessment of intrathecal antibody index.

Main Results:

  • Both patients presented with isolated ON, with one experiencing recurrence.
  • Differential diagnoses for multiple sclerosis and neuromyelitis optica were ruled out.
  • Positive serum and CSF serology for Borrelia burgdorferi confirmed neuroborreliosis.
  • Intrathecal anti-Borrelia antibody index was positive in both cases.
  • Both patients showed good visual recovery following intravenous ceftriaxone treatment.

Conclusions:

  • Lyme optic neuritis requires specific diagnostic consideration in endemic areas.
  • Early and accurate diagnosis through serological markers and antibody index is essential.
  • Prompt antibiotic treatment, such as ceftriaxone, leads to significant visual improvement, even with delayed intervention.