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Coronary artery calcification and coronary ischaemia in renal transplant recipients

Nurhan Seyahi1, Arzu Kahveci, Deniz Cebi

  • 1Department of Internal Medicine, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey. nseyahi@yahoo.com

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|July 13, 2010
PubMed

Insights

Coronary artery calcification (CAC) is common in kidney transplant patients and linked to coronary ischemia. Longer time since transplantation independently predicts CAC, highlighting the need for further prognostic studies.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Cardiovascular disease is the primary cause of death in renal transplant recipients.
  • Limited data exist on coronary artery calcification (CAC) and coronary ischemia in this population.
  • This study investigates CAC prevalence, determinants, and associated coronary ischemia in renal transplant patients.

Purpose of the Study:

  • To determine the prevalence and independent determinants of CAC in renal transplant recipients.
  • To assess the frequency of coronary ischemia in patients with moderate to severe CAC.
  • To explore the relationship between time on transplantation and CAC.

Main Methods:

  • 178 renal transplant recipients underwent multi-detector spiral computed tomography for CAC assessment using the Agatston score.
  • Rose questionnaire was used to identify angina pectoris.
  • Myocardial perfusion scintigraphy was performed in patients with moderate and severe CAC.
  • Multivariate logistic and linear regression analyses were employed.

Main Results:

  • CAC was present in 40.4% of patients (mean Agatston score: 113.7±275.5).
  • Independent determinants of CAC presence and high scores included age, time on transplantation, and Rose angina pectoris.
  • Coronary ischemia was detected in 17.1% of patients with moderate-to-severe CAC.

Conclusions:

  • CAC is highly prevalent in renal transplant recipients and associated with coronary ischemia symptoms.
  • Time on transplantation is an independent determinant of CAC.
  • Further research is needed to establish the prognostic value of CAC in this patient group.
Abstract

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