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Updated: Jun 11, 2026
06:49
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
Published on: November 20, 2016
Bilateral optic neuritis due to isoniazid (INH).
H S Kulkarni1, V S Keskar, S B Bavdekar
1Department of Ophthalmology, Seth GS Medical College and KEM Hospital, Parel, Mumbai, India.
Indian Pediatrics
|July 13, 2010
Summary
Optic nerve damage from isoniazid is rare in children but occurred in a 10-year-old treated for tuberculous meningitis. Symptoms improved after stopping isoniazid and using pyridoxine and steroids.
Area of Science:
- Pediatric Neurology
- Ophthalmology
- Infectious Diseases
Background:
- Isoniazid (INH) is a primary treatment for tuberculosis.
- Optic neuropathy is a known but rare side effect of INH therapy.
- Pediatric cases of INH-induced optic neuropathy are not well-documented.
Observation:
- A 10-year-old boy with tuberculous meningitis developed optic nerve involvement.
- The patient was undergoing treatment with isoniazid.
- Clinical presentation included visual disturbances indicative of optic neuropathy.
Findings:
- This case represents a rare instance of isoniazid-induced optic neuropathy in a pediatric patient.
- The adverse reaction was observed during treatment for tuberculous meningitis.
- Complete resolution of symptoms was achieved.
Implications:
- Highlights the potential for isoniazid to cause optic nerve damage in children.
- Emphasizes the importance of monitoring for visual disturbances during INH therapy in pediatric populations.
- Suggests pyridoxine and corticosteroid administration as effective management strategies for INH-induced optic neuropathy.
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