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Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

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Multiple echo SSFP sequences.

C T Mizumoto¹, E Yoshitome

¹Research and Development Division, Yokogawa Medical Systems, Ltd., Tokyo, Japan.

Magnetic Resonance in Medicine

|March 1, 1991

Summary

This summary is machine-generated.

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Researchers developed novel steady-state free precession (SSFP) imaging sequences to capture higher-order echoes. These echoes, though weaker, offer unique T1 and T2 contrast dependencies for advanced MRI applications.

Area of Science:

Magnetic Resonance Imaging (MRI)
Biophysics

Background:

Steady-state free precession (SSFP) sequences are widely used in MRI.
Higher-order echoes in SSFP imaging possess complex signal characteristics.
Existing SSFP methods have limitations in exploiting these complex echo properties.

Purpose of the Study:

To introduce a new type of SSFP imaging sequence for acquiring higher-order echoes.
To investigate the T1 and T2 dependencies of these higher-order echoes.
To explore the potential of these echoes for generating novel image contrasts.

Main Methods:

Development of novel SSFP pulse sequences.
Theoretical derivation of a steady-state equation for higher-order echoes.
Experimental acquisition and analysis of echo intensities.

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Main Results:

Successfully acquired higher-order echoes using the new SSFP sequences.
Presented a steady-state equation accurately describing T1 and T2 dependencies.
Observed weaker signal intensities compared to FID and CE-FAST echoes.
Demonstrated that higher-order echoes yield distinct contrast mechanisms.

Conclusions:

The novel SSFP sequences enable the acquisition of higher-order echoes.
These echoes exhibit unique T1 and T2 contrast dependencies.
The findings open possibilities for new MRI contrasts and applications.