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Updated: May 11, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
Published on: June 23, 2012
Multiple echo SSFP sequences
1Research and Development Division, Yokogawa Medical Systems, Ltd., Tokyo, Japan.
Abstract:
We report a new type of SSFP imaging sequences for acquiring higher-order echoes. Spins excited during a cycle have, in a sense, a phase memory such that they can be refocused several cycles down the line, and since the spins are pulsed under a steady-state condition, the resulting echoes have very complicated T1 and T2 dependencies. A steady-state equation, which describes the T1 and T2 dependencies for the higher-order echoes, is presented, and the intensity of each echo is calculated and compared with the experimental results. Although the signal intensity of the higher-order echoes are weaker than the FID or the CE-FAST echo, these echoes may be used to obtain images with different contrast dependencies previously unobtainable with either of the two signals.
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