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Evaluation of the protective effects of Chinese herbs against biomolecule damage induced by peroxynitrite

Yunjing Luo1, Jinglin Pan, Yanshu Pan

  • 1College of Life Science and Bioengineering, Beijing University of Technology, China. luoyj@bjut.edu.cn

Bioscience, Biotechnology, and Biochemistry
|July 13, 2010
PubMed

Insights

Chinese herbs like Propolis, Rosemary, and Pine Bark PE show strong peroxynitrite (ONOO(-)) scavenging activity. These natural compounds may help prevent diseases linked to biomolecule damage.

Area of Science:

  • Natural Product Chemistry
  • Biochemistry
  • Pharmacology

Background:

  • Peroxynitrite (ONOO(-)) is a reactive nitrogen species implicated in biomolecule damage.
  • Oxidative stress and associated damage are key factors in various pathologies.
  • Traditional Chinese medicine offers a rich source of potential therapeutic agents.

Purpose of the Study:

  • To evaluate the protective effects of Chinese herbs against ONOO(-)-induced damage.
  • To identify herbs with significant ONOO(-)-scavenging activity.
  • To investigate the potential of these herbs and their active components in preventing ONOO(-)-related diseases.

Main Methods:

  • Screening of 32 Chinese traditional herbs using a fluorometric method for ONOO(-)-scavenging activity.
  • Characterization of the inhibitory effects of selected extracts on DNA single breaks, tyrosine nitration, and LDL oxidation.
  • Analysis of active components responsible for ONOO(-)-scavenging.

Main Results:

  • Apis cerana Fabricius (Propolis), Rosmarinus officinalis L (Rosemary), Pseudolarix amabilis (Pine Bark PE), and Echinacea demonstrated high ONOO(-)-scavenging activity.
  • These four extracts effectively inhibited DNA single breaks, tyrosine nitration, and LDL oxidation.
  • Cichoric acid and rosemary acid were identified as major active components with potent ONOO(-)-scavenging abilities.

Conclusions:

  • Certain Chinese herbs possess significant ONOO(-)-scavenging properties.
  • Propolis, Rosemary, Pine Bark PE, and Echinacea extracts show promise for therapeutic development.
  • Active compounds like cichoric acid and rosemary acid may be valuable in preventing diseases associated with ONOO(-).

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