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Updated: Jun 11, 2026

Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Biotransformation of bioactive (-)-mellein by a marine isolate of bacterium Stappia sp
Zhile Feng1, Viviane Nenkep, Keumja Yun
1Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Abstract:
The biological transformation of the bioactive dihydroisocoumarin, (-)-mellein, isolated from the marine-derived fungus Cladosporium sp., was studied. The preparative-scale culture of (-)-mellein with a marine isolate of a bacterium Stappia sp. resulted in the isolation of its oxidized metabolite, (3R,4S)-4-hydroxymellein. The stereostructure of the metabolite obtained was assigned on the basis of detailed physicochemical data analyses.
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