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Sleep deprivation-induced neuronal damage may be due to nicotinic acid depletion
1Department of Pathology, Tulane University School of Medicine, New Orleans, LA 70112.
Medical Hypotheses
|March 1, 1991
Abstract:
Prolonged sleep deprivation induces chromatolysis of central nervous system neurons. This unusual form of neuronal damage is curiously similar to the neuronal damage seen in pellagra. It is proposed that the neuronal damage of prolonged sleep deprivation is a consequence of nicotinic acid depletion.