Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Kidney Transplant III: Nursing Management

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term kidney outcomes after living donation in older adults: clinical findings and equation-dependent eGFR estimates.

BMC geriatrics·2026

Same author

Renal transplantation in older recipients - results of the DZIF transplant cohort.

BMC geriatrics·2026

Same author

Health status of living kidney donors and attitude toward donation-Results from the German Living Donor Registry (SOLKID-GNR).

Frontiers in medicine·2026

Same author

Pathogen-specific epidemiology and clinical trajectories of fungal infections after kidney transplantation: a prospective multicenter cohort study.

BMC infectious diseases·2026

Same author

Editorial: Innovative approaches to immunogenetics and organ transplantation.

Frontiers in immunology·2026

Same author

Long-Term Outcomes Across Age and Risk Profiles in a Caucasian Living Kidney Donor Cohort.

Transplant international : official journal of the European Society for Organ Transplantation·2026

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Does borderline kidney allograft rejection always require treatment?

Dorottya Németh¹, Jörg Ovens, Gerhard Opelz

¹Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany.

Transplantation

|July 13, 2010

Summary

Regulatory T lymphocytes (Tregs) are key in borderline renal transplant rejection (Bord-R). Higher Foxp3 gene expression in Bord-R patients suggests current rejection treatments may be unnecessary for some.

More Related Videos

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using ¹⁸F-FDG PET

Published on: April 28, 2013

Related Experiment Videos

Last Updated: Jun 11, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using ¹⁸F-FDG PET

Published on: April 28, 2013

Area of Science:

Immunology
Transplantation Medicine
Molecular Biology

Background:

Borderline rejection (Bord-R) is common in renal transplantation.
Regulatory T lymphocytes (Tregs) are implicated in Bord-R pathogenesis.
Current diagnostics don't distinguish between graft-protective and -damaging T cells.

Purpose of the Study:

To analyze forkhead box P3 (Foxp3) gene expression in Tregs.
To compare Foxp3 levels in Bord-R versus acute rejection episodes (ARE).

Main Methods:

Measured Foxp3 transcripts in 520 peripheral blood samples.
Studied 177 kidney transplant recipients within 20 days post-transplantation.

Main Results:

Highest Foxp3 transcripts observed in Bord-R and non-rejection groups.
Lowest Foxp3 transcripts found in patients with ARE.
Bord-R patients showed significantly increased Foxp3 expression over time compared to ARE patients.

Conclusions:

Increased Treg activity in peripheral blood is characteristic of Bord-R.
This challenges the routine use of rejection treatment for all Bord-R diagnoses.