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NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose
Magnetic Resonance in Chemistry : MRC
|July 13, 2010
Abstract:
The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)-biotin starting from D-mannose as chiral pool were completely assigned using one- and two-dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC.
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