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Updated: Jun 11, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Cognitive behavioral therapy of obsessive-compulsive disorder
1Center for the Treatment and Study of Anxiety, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. foa@mail.med.upenn.edu
Obsessive-compulsive disorder (OCD) was once considered untreatable. The development of exposure and ritual prevention (EX/RP) in 1966 revolutionized OCD treatment, with current cognitive behavioral therapy (CBT) variants showing significant efficacy.
Area of Science:
- Psychiatry and Behavioral Science
- Clinical Psychology
Background:
- Obsessive-compulsive disorder (OCD) was historically viewed as highly resistant to treatment.
- Early interventions, including psychodynamic psychotherapy and medication, showed limited success in alleviating OCD symptoms.
Observation:
- The introduction of exposure and ritual prevention (EX/RP) in 1966 marked a significant turning point in OCD treatment.
- Cognitive behavioral conceptualizations have significantly influenced the development of effective OCD therapies.
Findings:
- Current cognitive behavioral therapy (CBT), particularly variants of EX/RP, demonstrates substantial empirical evidence for its efficacy in treating OCD.
- Cognitive behavioral treatments have become the leading approach for managing obsessive-compulsive disorder.
Implications:
- The evolution of CBT and EX/RP offers effective therapeutic options for individuals with obsessive-compulsive disorder.
- Further research into cognitive behavioral conceptualizations can refine and enhance treatments for OCD.
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