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Primary cutaneous anaplastic large cell lymphoma
Ghania Daar1, Serhan Küpeli, Bilgehan Yalçin
1Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Pediatric Hematology and Oncology
|July 14, 2010
Summary
Anaplastic large cell lymphoma (ALCL) is a rare skin cancer. This report details a unique case of a 15-year-old boy diagnosed with ALK-negative primary cutaneous ALCL, who responded well to chemotherapy.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Anaplastic large cell lymphoma (ALCL) is a T-cell lymphoid malignancy.
- Primary cutaneous ALCL (pcALCL) is a rare subtype, typically affecting elderly individuals.
- pcALCL presents as skin lesions and is characterized by CD30+ lymphoid cells.
Observation:
- A 15-year-old boy presented with a solitary left earlobe mass.
- The mass was initially misdiagnosed as keratoacanthoma.
- Histopathological and immunohistochemical analyses confirmed a T-cell phenotype.
Findings:
- The diagnosis was established as anaplastic lymphoma kinase (ALK)-negative primary cutaneous anaplastic large cell lymphoma.
- The patient exhibited a positive response to chemotherapy treatment.
- The case represents an unusual presentation of pcALCL in a pediatric patient.
Implications:
- This case highlights the importance of thorough histopathological and immunohistochemical evaluation for accurate diagnosis of rare skin lymphomas.
- Early diagnosis and prompt chemotherapy can lead to favorable outcomes in pediatric pcALCL.
- Further research into ALK-negative pcALCL in younger populations may be warranted.
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