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Macrolide and tetracycline resistance and emm type distribution of Streptococcus pyogenes isolates recovered from

Devrim Dundar1, Murat Sayan, Gulden Sonmez Tamer

  • 1Department of Microbioloy and Clinical Microbiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. devrimdundar@hotmail.com

Microbial Drug Resistance (Larchmont, N.Y.)
|July 14, 2010
PubMed

Insights

This study found that Streptococcus pyogenes strains in Turkey show resistance to erythromycin and tetracycline, with specific emm types predominating. Understanding this antibiotic resistance and emm type distribution is crucial for public health.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Streptococcus pyogenes is a significant human pathogen.
  • Antibiotic resistance in S. pyogenes is a growing global concern.
  • emm typing is essential for understanding S. pyogenes epidemiology.

Purpose of the Study:

  • To determine antibiotic susceptibilities to macrolides and tetracyclines in S. pyogenes.
  • To analyze the emm type distribution of S. pyogenes isolates.
  • To investigate the genetic basis of antibiotic resistance in S. pyogenes.

Main Methods:

  • Clinical isolates of S. pyogenes were collected from Kocaeli University Hospital, Turkey.
  • Antibiotic susceptibility testing was performed using standard methods.
  • emm typing and genotypic analysis of resistance genes (erm(TR), tet(O)) were conducted.

Main Results:

  • 9% of isolates were resistant to erythromycin, and 18% were resistant to tetracycline.
  • Inducible macrolide-lincosamide-streptogramin-C resistance phenotype and erm(TR) gene were observed in erythromycin-resistant isolates.
  • tet(O) was the predominant tetracycline resistance gene; emm types 4, 1, 2.114, and 89 were most common.

Conclusions:

  • Significant macrolide and tetracycline resistance exists in S. pyogenes in Turkey.
  • emm type heterogeneity was noted among resistant isolates.
  • This study provides initial insights into S. pyogenes emm type distribution and resistance patterns in Turkey, highlighting the need for further research.

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