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Related Concept Videos

Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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Lymphoid Cells and Tissues01:18

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Related Experiment Video

Updated: Jun 11, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Dilated lymphatics in Gottron's papules.

Angel Fernandez-Flores1

  • 1Service of Cellular Pathology,Clinica Ponferrada, Avenida Galicia 1, Ponferrada, Spain. gpyauflowerlion@terra.es

Acta Dermatovenerologica Croatica : ADC
|July 14, 2010
PubMed
Summary

Histopathology of Gottron

Area of Science:

  • Dermatopathology
  • Immunohistochemistry
  • Vascular Biology

Background:

  • Gottron's papules are characteristic skin lesions in dermatomyositis.
  • Previous histopathological studies primarily focused on epidermal and dermal inflammatory changes.
  • The vascular components, particularly lymphatic vessels, in these lesions remain under-characterized.

Observation:

  • This study investigated the vascular morphology of Gottron's papules using D2-40 antibody staining on a biopsy specimen.
  • The analysis aimed to characterize the nature of the vascular structures within these lesions.

Findings:

  • Histopathological examination revealed a mixed population of vascular vessels within the Gottron's papule.
  • While most vessels were identified as blood vessels (venules and capillaries), a significant subset were confirmed as dilated lymphatic vessels.

More Related Videos

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches
06:31

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Published on: June 25, 2020

Related Experiment Videos

Last Updated: Jun 11, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches
06:31

Microscopic Observation of Lymphocyte Dynamics in Rat Peyer's Patches

Published on: June 25, 2020

Implications:

  • The presence of dilated lymphatic vessels in Gottron's papules suggests a potential role for lymphatic involvement in the pathogenesis of dermatomyositis.
  • Further research into lymphatic dysfunction may offer novel therapeutic targets for this autoimmune condition.