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Immunomodulatory activity in vitro and in vivo of polysaccharide from Potentilla anserina
Jiong-Ran Chen1, Zhi-Qiang Yang, Ting-Jun Hu
1Lanzhou Institute of Animal Sciences and Veterinary Pharmaceutics, Chinese Academy of Agricultural Sciences, No. 335 Jiangouyan, Xiaoxihu, Lanzhou, Gansu 730050, PR China.
Abstract:
The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced. Phagocytotic and mononuclear phagocytic system function assays showed that PAP stimulated the phagocytosis of phagocyte. Splenocyte proliferation assay showed that PAP acted the effect combining Con A or LPS in splenocyte proliferation. The parameters detected showed that PAP increased thymus and spleen indices, the levels of LDH and ACP in the spleen, and IL-10 and IFN-γ in serum in immunosuppressed mice. The results suggest that PAP is involved in immunomodulatory effects leading to the exploration for PAP as a potential immunostimulant.
