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A microneedle roller for transdermal drug delivery
Jung-Hwan Park1, Seong-O Choi, Soonmin Seo
1Department of BioNano Technology and Gachon BioNano Research Institute, Kyungwon University, Seongnam, Republic of Korea. pa90201@kyungwon.ac.kr
Polymer microneedle rollers effectively create skin micro-holes for enhanced drug delivery, significantly increasing acetylsalicylic acid absorption compared to untreated skin. This novel approach offers a simpler method for improving skin permeability.
Area of Science:
- Biomaterials Engineering
- Dermal Science
- Drug Delivery Systems
Background:
- Microneedle rollers are utilized for cosmetic applications and enhancing skin permeability for drug delivery.
- Current methods face challenges in large-area treatment and efficient substance penetration.
Purpose of the Study:
- To introduce and evaluate a novel polymer microneedle roller fabricated using advanced lithography and micromolding techniques.
- To assess the efficacy of the microneedle roller in creating skin micro-channels and facilitating the delivery of various substances.
Main Methods:
- Fabrication of polymer microneedle rollers using inclined rotational UV lithography and micromolding with polylactic acid and carboxy-methyl-cellulose.
- Application of microneedle rollers to human and porcine cadaver skin to create micron-scale holes.
- Delivery of acetylsalicylic acid, Trypan blue, and nanoparticles (50nm and 200nm) through the created micro-channels.
- Analysis of drug delivery efficiency, lateral diffusion kinetics, and insertion force compared to flat patches.
Main Results:
- Microneedle rollers successfully created micron-scale holes in human and porcine skin, enabling the passage of drugs and nanoparticles.
- Acetylsalicylic acid delivery was 1-2 orders of magnitude greater than in untreated skin, correlating with the number of holes.
- Lateral diffusion of substances in the skin was observed with effective diffusivity values significantly lower than in water.
- Sequential row-by-row insertion using the roller required less force than flat patch insertion in porcine skin.
Conclusions:
- Polymer microneedle rollers, fabricated via replication, provide a straightforward and effective method for increasing skin permeability.
- This technology demonstrates significant potential for improving transdermal drug delivery efficiency.
- The microneedle roller design offers advantages in terms of insertion force and ease of application for large skin areas.
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