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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Jun 11, 2026

Microarray Analysis for Saccharomyces cerevisiae

Microarray Analysis for Saccharomyces cerevisiae

Published on: April 7, 2011

Toxicogenomics using yeast DNA microarrays.

Daisuke Yasokawa¹, Hitoshi Iwahashi

¹Hokkaido Food Processing Research Center, Department of Food Development, 589-4 Bunkyodai Midorimachi, Ebetsu, Hokkaido 0690836, Japan. yasokawa-daisuke@hro.or.jp

Journal of Bioscience and Bioengineering

|July 14, 2010

Summary

This summary is machine-generated.

Genomics and bioinformatics, using DNA microarrays in yeast, efficiently analyze cellular responses to toxic substances. This approach aids in understanding environmental stress impacts on gene expression and physiological conditions.

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Last Updated: Jun 11, 2026

Microarray Analysis for Saccharomyces cerevisiae

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Published on: April 7, 2011

Rapid Identification of Chemical Genetic Interactions in Saccharomyces cerevisiae

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Published on: April 5, 2015

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Published on: August 11, 2011

Area of Science:

Genomics and Bioinformatics
Toxicology
Molecular Biology

Background:

Genomics and bioinformatics enable global gene expression profiling via DNA microarrays.
Changes in gene expression reflect cellular physiological states.
Environmental stresses like toxic chemicals induce global genetic responses.

Purpose of the Study:

To review the application of yeast DNA microarrays in toxicogenomics.
To discuss the analysis of genetic responses to various chemical stressors.
To highlight Saccharomyces cerevisiae as a model organism for toxicity assessment.

Main Methods:

Utilizing DNA microarray technology to analyze gene expression profiles.
Employing Saccharomyces cerevisiae as a model eukaryotic system.
Compiling and reviewing existing toxicogenomic data.

Main Results:

Demonstrated the efficiency of DNA microarrays in analyzing global genetic responses to environmental stresses.
Highlighted the utility of yeast genomics due to extensive functional gene information.
Accumulated data supports yeast DNA microarrays for toxicity assessment.

Conclusions:

Yeast DNA microarrays are a powerful tool for toxicogenomic studies.
This approach facilitates rapid analysis of cellular responses to diverse chemical exposures.
Further research in yeast toxicogenomics can advance our understanding of chemical safety and environmental impact.