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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Refractive error, axial dimensions, and primary open-angle glaucoma: the Singapore Malay Eye Study
Shamira A Perera1, Tien Y Wong, Wan-Ting Tay
1Glaucoma Service, Singapore National Eye Centre, 11 Third Hospital Ave., Singapore.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 14, 2010
Summary
Moderate myopia and longer axial length (AL) are linked to primary open-angle glaucoma (POAG) in the Malay population. This association persists even after accounting for central corneal thickness (CCT).
Area of Science:
- Ophthalmology
- Public Health
- Genetics
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
- Understanding risk factors like refractive error and ocular biometry is crucial for early detection and prevention, particularly in diverse populations.
Purpose of the Study:
- To investigate the association between refractive error (myopia) and ocular biometric parameters (axial length, central corneal thickness) with POAG in the Malay population.
- To determine if these associations are independent of other known risk factors.
Main Methods:
- A population-based cross-sectional study (Singapore Malay Eye Study) involving 3280 participants aged 40-80 years.
- Standardized ophthalmic examinations included refraction, axial length (AL) and central corneal thickness (CCT) measurements.
- Glaucoma diagnosis followed established International Society for Geographical and Epidemiological Ophthalmology criteria.
Main Results:
- Moderate to high myopia (≤ -4.0 diopters) was significantly associated with POAG (OR 2.87), an association that remained after adjusting for CCT (OR 2.80).
- Increasing axial length (AL) showed a significant trend with POAG (P=.03).
- Participants with the longest AL (quartile 4) had a threefold increased odds of POAG compared to those with the shortest AL (quartile 1), even after controlling for CCT (OR 3.00).
Conclusions:
- Moderate myopia and increasing axial length are independent risk factors for primary open-angle glaucoma in the Malay population.
- These findings highlight the importance of considering refractive error and axial length in glaucoma screening and risk assessment.
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