Related Experiment Video
Updated: Jun 11, 2026
09:42
Motor Imagery Brain-Computer Interface in Rehabilitation of Upper Limb Motor Dysfunction After Stroke
Published on: September 1, 2023
Altered functional connectivity in the motor network after traumatic brain injury
M Kasahara1, D K Menon, C H Salmond
1Division of Anaesthesia, University Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. eas46@cam.ac.uk
Neurology
|July 14, 2010
Summary
Traumatic brain injury (TBI) survivors show altered motor network connectivity. Functional MRI reveals compromised activation and reduced interactions in TBI patients, suggesting network reorganization after injury.
Area of Science:
- Neuroscience
- Cognitive Science
- Neurology
Background:
- Persistent cognitive impairments are common in traumatic brain injury (TBI) survivors.
- TBI-induced damage may extend beyond visible lesions to remote brain networks.
- The motor network was investigated as a model to understand TBI-related connectivity changes.
Purpose of the Study:
- To investigate the integrity of the motor network in TBI survivors.
- To establish a proof of principle for abnormal connectivity in TBI.
- To explore functional reorganization in motor networks post-TBI.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used.
- 12 TBI patients and 9 healthy controls performed a finger-thumb opposition task.
- Conventional and psychophysiologic interaction (PPI) analyses examined functional connectivity.
Main Results:
- Controls showed significant activation in the motor cortex (M1), cerebellum (Ce), and supplementary motor area (SMA).
- TBI patients exhibited reduced M1 activation and altered connectivity patterns.
- Patients lacked negative interactions and showed reduced interhemispheric communication within the motor network.
Conclusions:
- TBI patients display compromised motor network activation and connectivity during a motor task.
- These findings suggest functional reorganization of motor networks following TBI.
- Abnormal connectivity may underlie persistent cognitive impairments in TBI survivors.
