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Impact of arterial load on left ventricular diastolic function in patients undergoing cardiac catheterization for

Hidekatsu Fukuta1, Nobuyuki Ohte, Kazuaki Wakami

  • 1Department of Cardio-Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. fukuta-h@med.nagoya-cu.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|July 14, 2010
PubMed

Insights

Increased augmentation index (AI) is linked to impaired left ventricular (LV) diastolic function in coronary artery disease (CAD) patients. Targeting late-systolic load may improve diastolic abnormalities.

Area of Science:

  • Cardiology
  • Vascular Physiology
  • Cardiac Imaging

Background:

  • Left ventricular (LV) diastolic dysfunction increases heart failure risk in coronary artery disease (CAD) patients.
  • No established treatments exist for diastolic abnormalities.
  • Chronic effects of increased LV afterload on diastolic function are not well understood.

Purpose of the Study:

  • To investigate the association between arterial load components and LV diastolic function indices.
  • To identify specific arterial load parameters that correlate with diastolic dysfunction in CAD patients.

Main Methods:

  • Studied 303 consecutive CAD patients undergoing cardiac catheterization.
  • Assessed arterial load using arterial compliance, total vascular resistance index, and augmentation index (AI).
  • Measured LV diastolic function via cardiac catheterization (Tau, EDP) and tissue Doppler echocardiography (E', E/E').

Main Results:

  • All arterial load components correlated with LV diastolic function indices.
  • Augmentation index (AI), reflecting late-systolic load, showed the strongest correlations.
  • AI independently associated with Tau, EDP, E', and E/E' after adjusting for confounders.

Conclusions:

  • Elevated AI is independently associated with impaired LV diastolic function in patients with CAD.
  • Late-systolic load, indicated by AI, may be a therapeutic target for improving diastolic abnormalities.
Abstract

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