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Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis

Goksel Cagirci1, Serkan Cay, Aytun Canga

  • 1Cardiology Clinic, Dışkapı Yıldırım Beyazıt Research and Educational Hospital, Ministry of Health, Turkey. goksel1977@yahoo.com

Journal of Cardiovascular Medicine (Hagerstown, Md.)
|July 14, 2010
PubMed

Insights

Asymmetrical dimethylarginine (ADMA) levels are significantly higher in patients with severe aortic valve stenosis. Elevated ADMA activity correlates with increased stenosis severity, suggesting its potential as a biomarker.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Aortic valve stenosis (AVS) is a prevalent valvular heart disease, often caused by calcification.
  • Calcific AVS involves inflammatory and cellular processes similar to atherosclerosis.
  • Asymmetrical dimethylarginine (ADMA) impairs nitric oxide bioavailability and causes endothelial dysfunction.

Purpose of the Study:

  • To investigate the association between ADMA activity and the severity of aortic valve stenosis.
  • To determine if ADMA levels can serve as a marker for AVS severity.

Main Methods:

  • A cohort of 109 patients was divided into mild, moderate, and severe aortic stenosis groups.
  • ADMA activity was quantified using an ELISA kit.

Main Results:

  • Mean ADMA activity was significantly elevated in the severe AVS group compared to mild and moderate groups (P < 0.001).
  • Serum ADMA activity showed a positive correlation with aortic gradient (mean and maximum) and a negative correlation with aortic valve area.

Conclusions:

  • Serum ADMA activity is notably higher in patients with severe aortic valve stenosis.
  • ADMA levels correlate positively with AVS severity.
  • ADMA may serve as a valuable biomarker for assessing and monitoring AVS progression.
Abstract

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