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Updated: Jun 11, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
Published on: May 15, 2019
Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin
Scott G Stewart1, Carlos J Braun, Marta E Polomska
1School of Biomedical, Biomolecular and Chemical Science, University of Western Australia, 35 Stirling Hwy, Crawley, 6009, WA, Australia. sgs@cyllene.uwa.edu.au
Abstract:
Herein we describe the synthesis of the first Thalidomide-biotin analogue in order to initiate investigations into the unknown molecular mode of action of Thalidomide. In this manner we describe the attachment of biotin tether through the Huisgen 1,3-dipolar cycloaddition or "click" synthetic methodology.
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