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Pediatric stroke: the importance of cerebral arteriopathy and vascular malformations

Lauren A Beslow1, Lori C Jordan

  • 1Division of Neurology, The Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|July 14, 2010
PubMed

Insights

Childhood stroke, a significant cause of pediatric morbidity, often results in long-term neurological issues. Cerebral arteriopathy and vascular malformations are key risk factors, necessitating further research for evidence-based care guidelines.

Area of Science:

  • Neurology
  • Pediatrics
  • Vascular Medicine

Background:

  • Childhood stroke incidence ranges from 2-13 per 100,000 person-years.
  • Over half of affected children experience long-term neurological sequelae.
  • Pediatric stroke is a heterogeneous disorder with significant morbidity.

Purpose of the Study:

  • Review recent literature on pediatric hemorrhagic and ischemic stroke.
  • Focus on cerebral arteriopathy and vascular malformations as stroke risk factors.
  • Examine diagnostic studies, outcomes, and practice variations in childhood stroke.

Main Methods:

  • Searched PubMed using terms: child, childhood, pediatric, stroke, ischemic, intracerebral hemorrhage, vasculopathy, vascular malformation.
  • Reviewed reference lists of identified articles for key publications.
  • Prioritized articles published since 2000, including seminal works.

Main Results:

  • Cerebral arteriopathy, including arterial dissection, may cause up to 80% of strokes in healthy children.
  • Children with cerebrovascular abnormalities face the highest recurrence risk (66% at 5 years for ischemic stroke).
  • Five-year recurrence risk for pediatric stroke is estimated between 5-19%.

Conclusions:

  • Pediatric stroke evaluation and treatment often lack evidence-based support.
  • Significant regional and geographic variations exist in pediatric stroke care practices.
  • Multicenter cohort studies and pediatric clinical trials are crucial for developing evidence-based guidelines.
Abstract

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