Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of recurrent facial ulcerations and dysesthesias from trigeminal trophic syndrome with chronic transcutaneous vagus nerve stimulation.

JAAD case reports·2026
Same author

Glaucoma Risk with Metformin and Sulfonylurea Therapies in Type 2 Diabetes: A Retrospective Cohort Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same author

Risk of Dementia in Type 2 Diabetes Patients With Open-Angle Glaucoma: Insights From a Nationwide Real-World Cohort Study.

American journal of ophthalmology·2026
Same author

Multi-omics qualification of an organ-on-a-chip model of osteolytic bone metastasis.

Acta biomaterialia·2025
Same author

The Developing Standards Landscape for Cell and Gene Therapies.

Advances in experimental medicine and biology·2025
Same author

Improvement in facial seborrheic dermatitis following cervical transcutaneous vagal nerve stimulation.

JAAD case reports·2025
Same journal

Zinc Finger Proteins as Regulators of Organ Fibrosis.

Journal of cellular biochemistry·2026
Same journal

Intrinsic Disorder Status in Human Proteins Interacting With SARS-CoV-2 Proteins: Insights From Five Years of Translational Research.

Journal of cellular biochemistry·2026
Same journal

The Effect of Protein Tagging on Aggregation and Phase Separation.

Journal of cellular biochemistry·2026
Same journal

TRIM32 Alleviates the Inflammation in Spinal Cord Injury Progression Through Inducing the Ubiquitination Degradation of TLR4.

Journal of cellular biochemistry·2026
Same journal

Bedaquiline Binding at the Leading Site of Mycobacterium tuberculosis ATP Synthase Induces Distinct Structural and Dynamic Changes.

Journal of cellular biochemistry·2026
Same journal

Agrin Ablation in Osteoblasts Compromises Long Bone Structure and Osteoblastic Differentiation of Mesenchymal Stem Cells.

Journal of cellular biochemistry·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
09:50

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

Published on: August 27, 2015

Stem cell mechanobiology.

David A Lee1, Martin M Knight, Jonathan J Campbell

  • 1University of London, London E1 4NS, UK. d.a.lee@qmul.ac.uk

Journal of Cellular Biochemistry
|July 14, 2010
PubMed
Summary
This summary is machine-generated.

Mechanical forces significantly influence stem cell differentiation. Stem cells sense and respond to environmental stiffness and external forces, leading to lineage-specific differentiation and the concept of a stem cell mechano-niche.

More Related Videos

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain
25:12

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

Published on: July 29, 2007

Related Experiment Videos

Last Updated: Jun 11, 2026

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro
09:50

A Simplified System for Evaluating Cell Mechanosensing and Durotaxis In Vitro

Published on: August 27, 2015

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain
25:12

Mechanical Stimulation of Stem Cells Using Cyclic Uniaxial Strain

Published on: July 29, 2007

Area of Science:

  • Mechanobiology
  • Stem Cell Biology
  • Biophysics

Background:

  • Stem cells possess self-maintenance and differentiation capabilities.
  • Physicochemical factors, particularly mechanical cues, regulate stem cell behavior.
  • The role of mechanical forces in stem cell differentiation is an emerging area of research.

Purpose of the Study:

  • To review current knowledge on the role of mechanical forces in inducing stem cell differentiation.
  • To explore how mechanical factors influence stem cell fate.
  • To propose a theoretical framework for stem cell maintenance and differentiation.

Main Methods:

  • Literature review of studies on stem cell differentiation and mechanical forces.
  • Analysis of how cellular and microenvironmental mechanical properties affect stem cell fate.
  • Synthesis of key themes from existing research.

Main Results:

  • Stem cell differentiation alters cellular and subcellular mechanical properties.
  • Stem cells detect and respond to microenvironmental stiffness, inducing lineage-specific differentiation.
  • External mechanical forces can initiate and drive stem cell differentiation through various mechanisms.

Conclusions:

  • A stem cell's mechanical properties, extracellular matrix stiffness, and external mechanical cues define a 'mechano-niche'.
  • This mechano-niche theory explains stem cell maintenance and differentiation.
  • Understanding mechanobiology is crucial for controlling stem cell behavior.