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Updated: Jun 11, 2026
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and biological evaluation of indolyl chalcones as antitumor agents
Dalip Kumar1, N Maruthi Kumar, Kanako Akamatsu
1Birla Institute of Technology and Science, Pilani, India. dalipk@bits-pilani.ac.in
Abstract:
A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC(50) values 0.03 and 0.09 microM, against PaCa-2 cell line, respectively.
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